Yes, you can. You will lose a lot of the magic for mobile nav transitions/animations, and the build optimizations in frameworks, and the speed of having an SPA from a framework. Here’s a simple proof-of-concept (POC), all in one index.html file. Of course, anything done with a CDN (like this example) can also be done by installing packages into your vanilla project with some kind of build tooling.
Hey dolthead, thank a lot!