Angular 5 + Ionic 3 (latest) + Desktop Browser combination

I want to use latest Angular 5, soon v6, with Ionic 3 which also will run in a desktop browser. I know IE11 is not supported but does it will work for desktops?

and is Ionic will work on Mobile Browser like the Mobile App with the same quality etc?

I am at a point I need to decide the UI components and want to be sure I am choosing right.